Age-related changes of glomerular basement membrane in normal rats.
نویسندگان
چکیده
منابع مشابه
Age-related changes of glomerular basement membrane in normal rats.
The structural changes of the renal glomeruli in development and aging were investigated by electron microscopy in normal rats from 4 to 36 weeks of age at 4 weeks intervals after birth. Infantile rats had an uneven glomerular basement membrane which was characterized by double-layered or mossy appearances of the lamina densa. On the other hand, diffuse and hemispherical thickenings of the base...
متن کاملBovine Glomerular Basement Membrane
The collagenous domain of bovine glomerular basement membrane was excised in soluble form by limited pepsin digestion and characterized. The domain amounts to approximately 25% of the whole membrane by weight. The constituent polypeptides were studied using several electrophoresis systems and amino acid analysis. The electrophoresis systems used were a combination of agarose and polyacrylamide...
متن کاملGlomerular Basement Membrane
The noncollagenous domain hexamer of collagen IV from bovine glomerular basement membrane was further investigated to determine the types of collagen chain from which subunits M2*b and M3 are derived. M2*b was shown to be a shorter form, containing 9 fewer residues, of M2*a which was previously established as the noncollagenous domain of a third chain, a3, of collagen IV (Saus, J., Wieslander, ...
متن کاملChanges in the molecular sieve of glomerular basement membrane in rats with aminonucleoside nephrosis.
Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the sh...
متن کاملAnti-glomerular basement membrane antibodies.
Basement membranes form an anatomic barrier that contains connective tissue. They are composed of type IV collagen, laminin and proteoglycans. Anti-basement membrane antibodies bind to the non-collagen site of the α3 chain of type IV collagen. A group of renal diseases, pulmonary diseases and perhaps others affecting different organs have long been associated with the presence of antibodies dir...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 1978
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.126.27